NOVEL FORMULATION DESIGN AND IN-VITRO EVALUATION OF EXTENDED RELEASE PELLETS BY COMPLEXATION TECHNIQUE

This research was undertaken with an aim to formulate dextromethorphan hydrobromide as extended release micropellets. The Preformulation studies were carried out on drug Dextromethorphane Hydrobromide and it shows that Drug has good flow property. Various ion exchange resins screened for complexation the ratio of drug: resin optimized along manufacturing process complexation. Drug-Resin complex further coated suitable hydrophobic rate retarding polymeric coatings using fluid bed processor. Optimization % Ethyl Cellulose coat drug-resin 23.5% EC selected preparing final batch micropellets Dextromethorphan hydrobromide.